Ontology highlight
ABSTRACT:
SUBMITTER: Goode TD
PROVIDER: S-EPMC11326193 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Goode Travis D TD Alipio Jason Bondoc JB Besnard Antoine A Pathak Devesh D Kritzer-Cheren Michael D MD Chung Ain A Duan Xin X Sahay Amar A
bioRxiv : the preprint server for biology 20240806
Adaptive regulation of feeding depends on linkage of internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation of a hippocampal-lateral hypothalamic area (LHA) network in binge eating, but mechanistic instantiation of underlying cell-types and circuitry is lacking. Here, we identify an evolutionary conserved and discrete Prodynorphin (<i>Pdyn</i>)-expressing subpopulation of Somatostatin (<i>Sst</i>)-expressing inhibitory neurons in the dorsolateral ...[more]