Ontology highlight
ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC11328608 | biostudies-literature | 2024 May
REPOSITORIES: biostudies-literature
Singh Ankita A Beaupre Michael M Villegas-Novoa Cecilia C Shiomitsu Kiyoshi K Gaudino Stephen J SJ Tawch Suzanne S Damle Ruhee R Kempen Cody C Choudhury Biswa B McAleer Jeremy P JP Sheridan Brian S BS Denoya Paula P Blumberg Richard S RS Hearing Patrick P Allbritton Nancy L NL Kumar Pawan P
Cell reports 20240511 5
The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1<sup>+</sup> cells (goblet and progenitor cells) is essential for maintaining the mucosal barrier and intestinal tissue r ...[more]