Dataset Information

Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

There is a close clinical association between hypothyroidism and nephrotic syndrome (NS) was close, but whether there is genetic causality between the two is not known.

Objective

Using pooled data from a genome-wide association study (GWAS), the association between hypothyroidism and NS was explored via Mendelian randomization (MR) analysis.

Methods

Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism (or NS) were screened as genetic instrumental variables (IVs) from pooled GWAS data, and inverse-variance weighting (IVW) was used for the main analysis to estimate causal effects, with MR-Egger, weighted median, and weighted mode used as complementary methods. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept, MR-PRESSO and leave-one-out, were also conducted to assess the robustness of the results.

Results

Genetically predicted hypothyroidism was positively associated with the risk of developing NS (IVW: OR = 1.18, 95% CI: 1.07-1.30, p = 0.00; MR-Egger: OR = 1.36, 95% CI: 1.10-1.68, p = 0.01), and the MR-Egger intercept (intercept = -0.02, p = 0.14), MR-PRESSO test (p = 0.14), Cochran's Q test (p = 0.15) and leave-one-out test results supported the robustness of the results. Genetically predicted NS status might not be associated with an increased risk of developing hypothyroidism (IVW: OR = 1.01, 95% CI: 1.00-1.03, p = 0.08; MR-Egger: OR = 1.01, 95% CI: 0.98-1.04, p = 0.43), and the MR-Egger intercept (intercept < 0.01, p = 0.69), MR-PRESSO test (p = 0.64), Cochran's Q test (p = 0.61) and leave-one-out test results supported the robustness of the results.

Conclusion

Hypothyroidism status could increase the risk of developing NS.

SUBMITTER: Liu C

PROVIDER: S-EPMC11328803 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature

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Publications

Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.

Liu Can C Shen Jiaxuan J Ding Zhaoran Z Duan Shuwen S Dai Enlai E

Renal failure 20240814 2

<h4>Background</h4>There is a close clinical association between hypothyroidism and nephrotic syndrome (NS) was close, but whether there is genetic causality between the two is not known.<h4>Objective</h4>Using pooled data from a genome-wide association study (GWAS), the association between hypothyroidism and NS was explored <i>via</i> Mendelian randomization (MR) analysis.<h4>Methods</h4>Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism (or NS) were screened as genetic instr ...[more]

PMID: 39143823

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Dataset Information

Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.

Background

Objective

Methods

Results

Conclusion

Publications

Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.

Similar Datasets

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