Ontology highlight
ABSTRACT:
SUBMITTER: Zhou RN
PROVIDER: S-EPMC11329635 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Zhou Ruo-Nan RN Zhu Zi-Wei ZW Xu Ping-Yuan PY Shen Li-Xuan LX Wang Ziwei Z Xue Ying-Ying YY Xiang Ying-Ying YY Cao Yue Y Yu Xi-Zhong XZ Zhao Juan J Jin Yu Y Yan Jing J Yang Qin Q Fang Peng-Hua PH Shang Wen-Bin WB
Communications biology 20240816 1
Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice. We construct a macrophage-adipocyte co-culture system and demonstrate that rhein promotes adipocyte thermogenesis through inhibiting NLRP3 inflammasome activation in macrophages. Moreover, clues from acetylome analysis identify SIRT2 as a potential drug target of rhein. We further verify ...[more]