Dataset Information

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using ¹⁸F-FDG PET/CT and nomogram integration.

ABSTRACT:

Background

The hyperinflammatory condition and lymphoproliferation due to Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) affect the detection of lymphomas by ¹⁸F-FDG PET/CT. We aimed to improve the diagnostic capabilities of ¹⁸F-FDG PET/CT by combining laboratory parameters.

Methods

This retrospective study involved 46 patients diagnosed with EBV-positive HLH, who underwent ¹⁸F-FDG PET/CT before beginning chemotherapy within a 4-year timeframe. These patients were categorized into two groups: EBV-associated HLH (EBV-HLH) (n = 31) and EBV-positive lymphoma-associated HLH (EBV + LA-HLH) (n = 15). We employed multivariable logistic regression and regression tree analysis to develop diagnostic models and assessed their efficacy in diagnosis and prognosis.

Results

A nomogram combining the SUVmax ratio, copies of plasma EBV-DNA, and IFN-γ reached 100% sensitivity and 81.8% specificity, with an AUC of 0.926 (95%CI, 0.779-0.988). Importantly, this nomogram also demonstrated predictive power for mortality in EBV-HLH patients, with a hazard ratio of 4.2 (95%CI, 1.1-16.5). The high-risk EBV-HLH patients identified by the nomogram had a similarly unfavorable prognosis as patients with lymphoma.

Conclusions

The study found that while ¹⁸F-FDG PET/CT alone has limitations in differentiating between lymphoma and EBV-HLH in patients with active EBV infection, the integration of a nomogram significantly improves the diagnostic accuracy and also exhibits a strong association with prognostic outcomes.

SUBMITTER: Yang X

PROVIDER: S-EPMC11330599 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using <sup>18</sup>F-FDG PET/CT and nomogram integration.

Yang Xu X Lu Xia X Feng Lijuan L Wang Wei W Kan Ying Y Zhang Shuxin S Li Xiang X Yang Jigang J

Cancer imaging : the official publication of the International Cancer Imaging Society 20240818 1

<h4>Background</h4>The hyperinflammatory condition and lymphoproliferation due to Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) affect the detection of lymphomas by <sup>18</sup>F-FDG PET/CT. We aimed to improve the diagnostic capabilities of <sup>18</sup>F-FDG PET/CT by combining laboratory parameters.<h4>Methods</h4>This retrospective study involved 46 patients diagnosed with EBV-positive HLH, who underwent <sup>18</sup>F-FDG PET/CT before beginning chemotherapy ...[more]

PMID: 39155389

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Dataset Information

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using ¹⁸F-FDG PET/CT and nomogram integration.

Background

Methods

Results

Conclusions

Publications

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using <sup>18</sup>F-FDG PET/CT and nomogram integration.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using 18F-FDG PET/CT and nomogram integration.

Background

Methods

Results

Conclusions

Publications

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using <sup>18</sup>F-FDG PET/CT and nomogram integration.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using ¹⁸F-FDG PET/CT and nomogram integration.