Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC11335263 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Zhu Saiya S Niu Yangyang Y Zhou Wenqian W Liu Yuqing Y Liu Jing J Liu Xi X Lu Limin L Yu Chen C
Cellular and molecular life sciences : CMLS 20240809 1
Copper is a trace element essential for numerous biological activities, whereas the mitochondria serve as both major sites of intracellular copper utilization and copper reservoir. Here, we investigated the impact of mitochondrial copper overload on the tricarboxylic acid cycle, renal senescence and fibrosis. We found that copper ion levels are significantly elevated in the mitochondria in fibrotic kidney tissues, which are accompanied by reduced pyruvate dehydrogenase (PDH) activity, mitochondr ...[more]