Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC11338233 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Xu Yunxia Y Wu Yaqi Y Zhang Yuanyuan Y Gao Kaiting K Wu Xiaoying X Yang Yaxue Y Li Danyang D Yang Biao B Zhang Zhengyu Z Dong Changjiang C
Science advances 20240821 34
An outbreak of mpox virus in May 2022 has spread over 110 nonpandemic regions in the world, posing a great threat to global health. Mpox virus E5, a helicase-primase, plays an essential role in DNA replication, but the molecular mechanisms are elusive. Here, we report seven structures of mpox virus E5 in a double hexamer (DH) and six in single hexamer in different conformations, indicating a rotation mechanism for helicase and a coupling action for primase. The DH is formed through the interface ...[more]