Ontology highlight
ABSTRACT:
SUBMITTER: Bahk K
PROVIDER: S-EPMC11339604 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Bahk Kunhyung K Sung Joohon J Seki Mitsuko M Kim Kyungjong K Kim Jina J Choi Hongjo H Whang Jake J Mitarai Satoshi S
DNA research : an international journal for rapid publication of reports on genes and genomes 20240801 4
In Mycobacterium tuberculosis (MTB) control, whole genome sequencing-based molecular drug susceptibility testing (molDST-WGS) has emerged as a pivotal tool. However, the current reliance on a single-strain reference limits molDST-WGS's true potential. To address this, we introduce a new pan-lineage reference genome, 'MtbRf'. We assembled 'unmapped' reads from 3,614 MTB genomes (751 L1; 881 L2; 1,700 L3; and 282 L4) into 35 shared, annotated contigs (54 coding sequences [CDSs]). We constructed Mt ...[more]