Ontology highlight
ABSTRACT:
SUBMITTER: Pena-Diaz S
PROVIDER: S-EPMC11340618 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Peña-Díaz Sandra S Chao Joseph D JD Rens Celine C Haghdadi Hasti H Zheng Xingji X Flanagan Keegan K Ko Mary M Shapira Tirosh T Richter Adrian A Maestre-Batlle Danay D Canseco Julio Ortiz JO Gutierrez Maximiliano Gabriel MG Duc Khanh Dao KD Pelech Steven S Av-Gay Yossef Y
iScience 20240720 8
Compounds targeting host control of infectious diseases provide an attractive alternative to antimicrobials. A phenotypic screen of a kinase library identified compounds targeting glycogen synthase kinase 3 as potent inhibitors of <i>Mycobacterium tuberculosis</i> (Mtb) intracellular growth in the human THP-1 cell line and primary human monocytes-derived macrophages (hMDM). CRISPR knockouts and siRNA silencing showed that GSK3 isoforms are needed for the growth of Mtb and that a selected compoun ...[more]