RNA thermometers are widespread upstream of ABC transporter genes in bacteria.
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ABSTRACT:
SUBMITTER: Tong AY
PROVIDER: S-EPMC11342760 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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RNA thermometers are widespread upstream of ABC transporter genes in bacteria.
Tong Alina Y AY Tong Elisha L EL Hannani Michael A MA Shaffer Samantha N SN Santiago Danna D Ferré-D'Amaré Adrian R AR Passalacqua Luiz F M LFM Abdelsayed Michael M MM
The Journal of biological chemistry 20240709 8
RNA thermometers are temperature-sensing non-coding RNAs that regulate the expression of downstream genes. A well-characterized RNA thermometer motif discovered in bacteria is the ROSE-like element (repression of heat shock gene expression). ATP-binding cassette (ABC) transporters are a superfamily of transmembrane proteins that harness ATP hydrolysis to facilitate the export and import of substrates across cellular membranes. Through structure-guided bioinformatics, we discovered that ROSE-like ...[more]
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