Ontology highlight
ABSTRACT:
SUBMITTER: Cybulla E
PROVIDER: S-EPMC11347138 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Cybulla Emily E Wallace Sierra S Meroni Alice A Jackson Jessica J Agashe Sumedha S Tennakoon Mithila M Limbu Mangsi M Quinet Annabel A Lomonosova Elena E Noia Hollie H Tirman Stephanie S Wood Matthew M Lemacon Delphine D Fuh Katherine K Zou Lee L Vindigni Alessandro A
Nucleic acids research 20240801 15
BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic degradation. In BRCA1/2-deficient cancer cells, extensively degraded replication forks can be rescued through distinct fork recovery mechanisms that also promote cell survival. Here, we identified a novel pathway mediated by the E3 ubiquitin ligase RAD18, the E2-conjugating enzyme UBC13, the recombination fac ...[more]