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Heat-killed Bifidobacterium longum BBMN68 and inulin protect against high-fat diet-induced obesity by modulating gut microbiota.


ABSTRACT:

Introduction

Obesity, a pervasive global epidemic, has heightened susceptibility to chronic ailments and diminished the overall life expectancy on a global scale. Probiotics and inulin (IN) have been documented to mitigate obesity by exerting an influence on the composition of the gut microbiota. Whether heat-killed Bifidobacterium longum BBMN68 (MN68) and IN have an anti-obesity effect remains to be investigated.

Methods

In this study, Wistar rats were fed a high-fat diet (HFD), and orally administered heat-killed MN68 (2 × 1011 CFU/kg) and/or inulin (0.25 kg/kg) for 12 weeks. Histological analysis, serology analysis and 16S rRNA gene sequencing were performed.

Results

Heat-killed MN68 + IN treatment showed an enhanced effect on preventing weight gain, diminishing fat accumulation, and regulating lipid metabolism, compared to either heat-killed MN68 treatment or inulin treatment. Gut microbiota results showed that heat-killed MN68 + IN treatment significantly increased the relative abundance of Bacteroidota, Oscillospira, Intestinimonas, Christensenella, and Candidatus_Stoquefichus, and reduced the relative abundance of Enterococcus. Furthermore, heat-killed MN68 + IN significantly increased the SCFA levels, which were correlated with changes in the gut microbiota.

Discussion

This research provides support for the application of heat-killed MN68 and IN in the treatment of obesity, and highlights the combination of heat-killed BBMN68 and IN as functional food ingredients.

SUBMITTER: Sun S 

PROVIDER: S-EPMC11351561 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Heat-killed <i>Bifidobacterium longum</i> BBMN68 and inulin protect against high-fat diet-induced obesity by modulating gut microbiota.

Sun Siyuan S   Zhang Qi Q   Li Dongdong D   Li Hongliang H   Ma Hairan H   Wu Xiuying X   Li Yixuan Y   Wang Pengjie P   Liu Rong R   Feng Haihong H   Zhang Yongxiang Y   Sang Yue Y   Fang Bing B   Wang Ran R  

Frontiers in nutrition 20240814


<h4>Introduction</h4>Obesity, a pervasive global epidemic, has heightened susceptibility to chronic ailments and diminished the overall life expectancy on a global scale. Probiotics and inulin (IN) have been documented to mitigate obesity by exerting an influence on the composition of the gut microbiota. Whether heat-killed <i>Bifidobacterium longum</i> BBMN68 (MN68) and IN have an anti-obesity effect remains to be investigated.<h4>Methods</h4>In this study, Wistar rats were fed a high-fat diet  ...[more]

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