Ontology highlight
ABSTRACT:
SUBMITTER: De Luca M
PROVIDER: S-EPMC11355036 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
De Luca Maria M Musio Biagia B Balestra Francesco F Arrè Valentina V Negro Roberto R Depalo Nicoletta N Rizzi Federica F Mastrogiacomo Rita R Panzetta Giorgia G Donghia Rossella R Pesole Pasqua Letizia PL Coletta Sergio S Piccinno Emanuele E Scalavino Viviana V Serino Grazia G Maqoud Fatima F Russo Francesco F Orlando Antonella A Todisco Stefano S Mastrorilli Pietro P Curri Maria Lucia ML Gallo Vito V Giannelli Gianluigi G Scavo Maria Principia MP
International journal of molecular sciences 20240814 16
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) affecting the gastrointestinal tract that can also cause extra-intestinal complications. Following exposure to the mRNA vaccine BNT162b2 (Pfizer-BioNTech) encoding the SARS-CoV-2 Spike (S) protein, some patients experienced a lack of response to the biological drug Adalimumab and a recrudescence of the disease. In CD patients in progression, resistant to considered biological therapy, an abnormal increase in intestinal permeabili ...[more]