Ontology highlight
ABSTRACT:
SUBMITTER: Ilari S
PROVIDER: S-EPMC11357234 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Ilari Sara S Nucera Saverio S Passacatini Lucia Carmela LC Scarano Federica F Macrì Roberta R Caminiti Rosamaria R Ruga Stefano S Serra Maria M Giancotti Luigino Antonio LA Lauro Filomena F Dagostino Concetta C Mazza Valeria V Ritorto Giovanna G Oppedisano Francesca F Maiuolo Jessica J Palma Ernesto E Malafoglia Valentina V Tomino Carlo C Mollace Vincenzo V Muscoli Carolina C
Nutrients 20240809 16
Morphine is an important pain reliever employed in pain management, its extended utilize is hindered by the onset of analgesic tolerance and oxidative stress. Long-term morphine administration causes elevated production of reactive oxygen species (ROS), disrupting mitochondrial function and inducing oxidation. Sirtuin 3 (SIRT3), a mitochondrial protein, is essential in modulating ROS levels by regulating mitochondrial antioxidant enzymes as manganese superoxide dismutase (MnSOD). Our investigati ...[more]