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Insights into Peptidyl-Prolyl cis-trans Isomerases from Clinically Important Protozoans: From Structure to Potential Biotechnological Applications.


ABSTRACT: Peptidyl-prolyl cis/trans isomerases (PPIases) are present in a wide variety of microorganisms, including protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, Trichomonas vaginalis, Leishmania major, Leishmania donovani, Plasmodium falciparum, Plasmodium vivax, Entamoeba histolytica, Giardia intestinalis, Cryptosporidium parvum, and Cryptosporidium hominis, all of which cause important neglected diseases. PPIases are classified as cyclophilins, FKBPs, or parvulins and play crucial roles in catalyzing the cis-trans isomerization of the peptide bond preceding a proline residue. This activity assists in correct protein folding. However, experimentally, the biological structure-function characterization of PPIases from these protozoan parasites has been poorly addressed. The recombinant production of these enzymes is highly relevant for this ongoing research. Thus, this review explores the structural diversity, functions, recombinant production, activity, and inhibition of protozoan PPIases. We also highlight their potential as biotechnological tools for the in vitro refolding of other recombinant proteins from these parasites. These applications are invaluable for the development of diagnostic and therapeutic tools.

SUBMITTER: Aranda-Chan V 

PROVIDER: S-EPMC11357558 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Insights into Peptidyl-Prolyl <i>cis</i>-<i>trans</i> Isomerases from Clinically Important Protozoans: From Structure to Potential Biotechnological Applications.

Aranda-Chan Verónica V   Cárdenas-Guerra Rosa Elena RE   Otero-Pedraza Alejandro A   Pacindo-Cabrales Esdras Enoc EE   Flores-Pucheta Claudia Ivonne CI   Montes-Flores Octavio O   Arroyo Rossana R   Ortega-López Jaime J  

Pathogens (Basel, Switzerland) 20240731 8


Peptidyl-prolyl <i>cis</i>/<i>trans</i> isomerases (PPIases) are present in a wide variety of microorganisms, including protozoan parasites such as <i>Trypanosoma cruzi</i>, <i>Trypanosoma brucei</i>, <i>Trichomonas vaginalis</i>, <i>Leishmania major</i>, <i>Leishmania donovani</i>, <i>Plasmodium falciparum</i>, <i>Plasmodium vivax</i>, <i>Entamoeba histolytica</i>, <i>Giardia intestinalis</i>, <i>Cryptosporidium parvum</i>, and <i>Cryptosporidium hominis</i>, all of which cause important neglec  ...[more]

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