Ontology highlight
ABSTRACT:
SUBMITTER: Jin Z
PROVIDER: S-EPMC11362843 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Jin Zhen Z Mao Yan Y Guo Qiqi Q Yin Yujing Y Kiram Abdukahar A Zhou Danxia D Yang Jing J Zhou Zheng Z Xue Jiachen J Feng Zhenhua Z Liu Zhen Z Qiu Yong Y Fu Tingting T Gan Zhenji Z Zhu Zezhang Z
Research (Washington, D.C.) 20240830
Although microgravity has been implicated in osteoporosis, the precise molecular mechanism remains elusive. Here, we found that microgravity might induce mitochondrial protein buildup in skeletal muscle, alongside reduced levels of LONP1 protein. We revealed that disruptions in mitochondrial proteolysis, induced by the targeted skeletal muscle-specific deletion of the essential mitochondrial protease LONP1 or by the acute inducible deletion of muscle LONP1 in adult mice, cause reduced bone mass ...[more]