Ontology highlight
ABSTRACT:
SUBMITTER: Niu H
PROVIDER: S-EPMC11366033 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Niu Han H Maruoka Masahiro M Noguchi Yuki Y Kosako Hidetaka H Suzuki Jun J
Nature communications 20240831 1
Cells establish the asymmetrical distribution of phospholipids and alter their distribution by phospholipid scrambling (PLS) to adapt to environmental changes. Here, we demonstrate that a protein complex, consisting of the ion channel Tmem63b and the thiamine transporter Slc19a2, induces PLS upon calcium (Ca<sup>2+</sup>) stimulation. Through revival screening using a CRISPR sgRNA library on high PLS cells, we identify Tmem63b as a PLS-inducing factor. Ca<sup>2+</sup> stimulation-mediated PLS is ...[more]