Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC11367924 | biostudies-literature | 2024 Sep
REPOSITORIES: biostudies-literature
Chen Jianmei J Qiu Shuo S Liu Yang Y Sun Wenqi W Zhou Tian T Zhao Lianbi L Li Zhelong Z Duan Yunyou Y
Journal of nanobiotechnology 20240902 1
Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that cardiac ferroptosis induced by DOX in mice was attributed to up-regulation of Hmox1, as knockdown of Hmox1 effectively inhibited cardiomyocyte ferroptosis. To targeted delivery of siRNA into cardiomyocytes, siRNA-encapsulated exosomes were injected followed by ult ...[more]