Ontology highlight
ABSTRACT:
SUBMITTER: Poirion OB
PROVIDER: S-EPMC11368035 | biostudies-literature | 2024 Sep
REPOSITORIES: biostudies-literature
Poirion Olivier B OB Zuo Wulin W Spruce Catrina C Baker Candice N CN Daigle Sandra L SL Olson Ashley A Skelly Daniel A DA Chesler Elissa J EJ Baker Christopher L CL White Brian S BS
Genome biology 20240902 1
Enhlink is a computational tool for scATAC-seq data analysis, facilitating precise interrogation of enhancer function at the single-cell level. It employs an ensemble approach incorporating technical and biological covariates to infer condition-specific regulatory DNA linkages. Enhlink can integrate multi-omic data for enhanced specificity, when available. Evaluation with simulated and real data, including multi-omic datasets from the mouse striatum and novel promoter capture Hi-C data, demonstr ...[more]