Dataset Information

HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21.

ABSTRACT:

Background

Transmitted drug resistance (TDR) is still a critical aspect for the management of individuals living with HIV-1. Thus, its evaluation is crucial to optimize HIV care.

Methods

Overall, 2386 HIV-1 protease/reverse transcriptase and 1831 integrase sequences from drug-naïve individuals diagnosed in north and central Italy between 2015 and 2021 were analysed. TDR was evaluated over time. Phylogeny was generated by maximum likelihood. Factors associated with TDR were evaluated by logistic regression.

Results

Individuals were mainly male (79.1%) and Italian (56.2%), with a median (IQR) age of 38 (30-48). Non-B infected individuals accounted for 44.6% (N = 1065) of the overall population and increased over time (2015-2021, from 42.1% to 51.0%, P = 0.002). TDR prevalence to any class was 8.0% (B subtype 9.5% versus non-B subtypes 6.1%, P = 0.002) and remained almost constant over time. Overall, 300 transmission clusters (TCs) involving 1155 (48.4%) individuals were identified, with a similar proportion in B and non-infected individuals (49.7% versus 46.8%, P = 0.148). A similar prevalence of TDR among individuals in TCs and those out of TCs was found (8.2% versus 7.8%, P = 0.707).By multivariable analysis, subtypes A, F, and CFR02_AG were negatively associated with TDR. No other factors, including being part of TCs, were significantly associated with TDR.

Conclusions

Between 2015 and 2021, TDR prevalence in Italy was 8% and remained almost stable over time. Resistant strains were found circulating regardless of being in TCs, but less likely in non-B subtypes. These results highlight the importance of a continuous surveillance of newly diagnosed individuals for evidence of TDR to inform clinical practice.

SUBMITTER: Fabeni L

PROVIDER: S-EPMC11368429 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Publications

HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21.

Fabeni Lavinia L Armenia Daniele D Abbate Isabella I Gagliardini Roberta R Mazzotta Valentina V Bertoli Ada A Gennari William W Forbici Federica F Berno Giulia G Piermatteo Lorenzo L Borghi Vanni V Pinnetti Carmela C Vergori Alessandra A Mondi Annalisa A Parruti Giustino G Di Sora Fiorella F Iannetta Marco M Lichtner Miriam M Latini Alessandra A Mussini Cristina C Sarmati Loredana L Perno Carlo Federico CF Girardi Enrico E Antinori Andrea A Ceccherini-Silberstein Francesca F Maggi Fabrizio F Santoro Maria Mercedes MM

The Journal of antimicrobial chemotherapy 20240901 9

<h4>Background</h4>Transmitted drug resistance (TDR) is still a critical aspect for the management of individuals living with HIV-1. Thus, its evaluation is crucial to optimize HIV care.<h4>Methods</h4>Overall, 2386 HIV-1 protease/reverse transcriptase and 1831 integrase sequences from drug-naïve individuals diagnosed in north and central Italy between 2015 and 2021 were analysed. TDR was evaluated over time. Phylogeny was generated by maximum likelihood. Factors associated with TDR were evaluat ...[more]

PMID: 39028674

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Dataset Information

HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21.

Background

Methods

Results

Conclusions

Publications

HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21.

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