Ontology highlight
ABSTRACT:
SUBMITTER: Maciag G
PROVIDER: S-EPMC11368673 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Maciag Grzegorz G Hansen Stine Lind SL Krizic Kata K Kellermann Lauge L Inventor Zøylner Maureen Joy MJ Ulyanchenko Svetlana S Maimets Martti M Baattrup Astrid Møller AM Riis Lene Buhl LB Khodosevich Konstantin K Sato Toshiro T Bressan Raul Bardini RB Nielsen Ole Haagen OH Jensen Kim B KB
Stem cell reports 20240718 8
The intestinal epithelium ensures uptake of vital nutrients and acts as a barrier between luminal contents and the underlying immune system. In inflammatory bowel diseases, such as ulcerative colitis (UC), this barrier is compromised, and patients experience debilitating symptoms. Here, we perform single-cell RNA profiling of epithelial cells and outline patterns of cell fate decisions in healthy individuals and UC patients. We demonstrate that patterns of hierarchical behavior are altered in UC ...[more]