Linkage disequilibrium maps and association mapping.
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ABSTRACT:
SUBMITTER: Morton NE
PROVIDER: S-EPMC1137007 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Publications
Linkage disequilibrium maps and association mapping.
The Journal of clinical investigation 20050601 6
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described. ...[more]
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