Epigenetic silencing of KCTD8 promotes hepatocellular carcinoma growth by activating PI3K/AKT signaling.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC11370965 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
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Epigenetic silencing of <i>KCTD8</i> promotes hepatocellular carcinoma growth by activating PI3K/AKT signaling.
Zhou Jing J Zhang Meiying M Gao Aiai A Herman James G JG Guo Mingzhou M
Epigenomics 20240718 13
<b>Aim:</b> The aim of current study is to explore the epigenetic changes and function of KCTD8 in human hepatocellular carcinoma (HCC). <b>Materials & methods:</b> HCC cell lines and tissue samples were employed. Methylation specific PCR, flow cytometry, immunoprecipitation and xenograft mouse models were used.<b>Results:</b> <i>KCTD8</i> was methylated in 44.83% (104/232) of HCC and its methylation may act as an independent poor prognostic marker. KCTD8 expression was regulated by DNA methylat ...[more]
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