Ontology highlight
ABSTRACT:
SUBMITTER: Puighermanal E
PROVIDER: S-EPMC11375224 | biostudies-literature | 2024 Sep
REPOSITORIES: biostudies-literature
Nature communications 20240904 1
Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) is the most common pediatric MD and is characterized by progressive neuromuscular affectation and premature death. Here, we show that daily cannabidiol (CBD) administration significantly extends lifespan and ameliorates pathology in two LS mouse models, and improves cellular function in fibroblasts from LS patients. CBD delays ...[more]