Herpes simplex virus triggers and then disarms a host antiviral response.
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ABSTRACT:
SUBMITTER: Mossman KL
PROVIDER: S-EPMC113971 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Publications
Herpes simplex virus triggers and then disarms a host antiviral response.
Mossman K L KL Macgregor P F PF Rozmus J J JJ Goryachev A B AB Edwards A M AM Smiley J R JR
Journal of virology 20010101 2
Virus infection induces an antiviral response that is predominantly associated with the synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type 1 virions induce an interferon-independent antiviral state in human embryonic lung cells that prevents plaquing of a variety of viruses. Microarray analysis of 19,000 human expressed sequence tags revealed induction of a limited set of host genes, the majority of which are also induced by interferon. Genes implicated ...[more]
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