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Highly prevalent putative quadruplex sequence motifs in human DNA.

ABSTRACT: We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.

SUBMITTER: Todd AK

PROVIDER: S-EPMC1140077 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature

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Highly prevalent putative quadruplex sequence motifs in human DNA.

Todd Alan K AK Johnston Matthew M Neidle Stephen S

Nucleic acids research 20050524 9

We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex c ...[more]

PMID: 15914666

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