Ontology highlight
ABSTRACT:
SUBMITTER: Arbel M
PROVIDER: S-EPMC1140443 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Arbel Michal M Yacoby Iftach I Solomon Beka B
Proceedings of the National Academy of Sciences of the United States of America 20050513 21
Amyloid-beta peptide (AbetaP) that accumulates in the Alzheimer's diseased brain is derived from proteolytic processing of the amyloid precursor protein (APP) by means of beta- and gamma-secretases. The beta-secretase APP cleaving enzyme (BACE), which generates the N terminus of AbetaP, has become a target of intense research aimed at blocking the enzyme activity, thus reducing AbetaP and, subsequently, plaque formation. The search for specific inhibitors of beta-secretase activity as a possible ...[more]