Emergence in Asia of foot-and-mouth disease viruses with altered host range: characterization of alterations in the 3A protein.
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ABSTRACT:
SUBMITTER: Knowles NJ
PROVIDER: S-EPMC114061 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Publications
Emergence in Asia of foot-and-mouth disease viruses with altered host range: characterization of alterations in the 3A protein.
Knowles N J NJ Davies P R PR Henry T T O'Donnell V V Pacheco J M JM Mason P W PW
Journal of virology 20010201 3
In 1997, an epizootic in Taiwan, Province of China, was caused by a type O foot-and-mouth disease virus which infected pigs but not cattle. The virus had an altered 3A protein, which harbored a 10-amino-acid deletion and a series of substitutions. Here we show that this deletion is present in the earliest type O virus examined from the region (from 1970), whereas substitutions surrounding the deletion accumulated over the last 29 years. Analyses of the growth of these viruses in bovine cells sug ...[more]
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