Ontology highlight
ABSTRACT:
SUBMITTER: Sapir T
PROVIDER: S-EPMC1142350 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Sapir Tamar T Shternhall Keren K Meivar-Levy Irit I Blumenfeld Tamar T Cohen Hamutal H Skutelsky Ehud E Eventov-Friedman Smadar S Barshack Iris I Goldberg Iris I Pri-Chen Sarah S Ben-Dor Lya L Polak-Charcon Sylvie S Karasik Avraham A Shimon Ilan I Mor Eytan E Ferber Sarah S
Proceedings of the National Academy of Sciences of the United States of America 20050517 22
Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression severely restrict the large-scale application of cell-replacement therapy for diabetic patients. This study suggests the potential use of adult human liver as alternate tissue for autologous beta-cell-replacement therapy. By using pancreatic and duodenal homeobox gene 1 (PDX-1) and soluble factors, we induced a comprehensive developmental shift of adult human liver cells into functional insulin-produ ...[more]