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Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.


ABSTRACT: We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.

SUBMITTER: Islam SA 

PROVIDER: S-EPMC114246 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature

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Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.

Islam S A SA   Hay C M CM   Hartman K E KE   He S S   Shea A K AK   Trocha A K AK   Dynan M J MJ   Reshamwala N N   Buchbinder S P SP   Basgoz N O NO   Kalams S A SA  

Journal of virology 20010501 10


We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection. ...[more]

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