Ontology highlight
ABSTRACT:
SUBMITTER: Muncke N
PROVIDER: S-EPMC1142516 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
BMC medical genetics 20050512
<h4>Background</h4>PITX2 is a bicoid-related homeodomain transcription factor that plays an important role in asymmetric cardiogenesis. Loss of function experiments in mice cause severe heart malformations, including transposition of the great arteries (TGA). TGA accounts for 5-7% of all congenital heart diseases affecting 0.2 per 1000 live births, thereby representing the most frequent cyanotic heart defect diagnosed in the neonatal period.<h4>Methods</h4>To address whether altered PITX2 functi ...[more]