The many faces of protease-protein inhibitor interaction.
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ABSTRACT:
SUBMITTER: Otlewski J
PROVIDER: S-EPMC1142537 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Publications
The many faces of protease-protein inhibitor interaction.
Otlewski Jacek J Jelen Filip F Zakrzewska Malgorzata M Oleksy Arkadiusz A
The EMBO journal 20050303 7
Proteases and their natural protein inhibitors are among the most intensively studied protein-protein complexes. There are about 30 structurally distinct inhibitor families that are able to block serine, cysteine, metallo- and aspartyl proteases. The mechanisms of inhibition can be related to the catalytic mechanism of protease action or include a mechanism-unrelated steric blockage of the active site or its neighborhood. The structural elements that are responsible for the inhibition most often ...[more]
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