Ontology highlight
ABSTRACT:
SUBMITTER: Inada T
PROVIDER: S-EPMC1142571 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Inada Toshifumi T Aiba Hiroji H
The EMBO journal 20050331 8
A novel mRNA surveillance for mRNA lacking a termination codon (nonstop mRNA) has been proposed in which Ski7p is thought to recognize stalled ribosomes at the 3' end of mRNA. Here we report our analysis of translation and decay of nonstop mRNAs in Saccharomyces cerevisiae. Although the reduction of nonstop mRNAs was only 4.5-fold, a level that is sufficient for residual protein synthesis, translation products of nonstop mRNAs were hardly detectable. We show that nonstop mRNAs were associated wi ...[more]