Ontology highlight
ABSTRACT:
SUBMITTER: Medina MG
PROVIDER: S-EPMC1142582 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Medina Manel G MG Ledesma Maria Dolores MD Domínguez Jorge E JE Medina Miguel M Zafra Delia D Alameda Francesc F Dotti Carlos G CG Navarro Pilar P
The EMBO journal 20050421 9
Tissue plasminogen activator (tPA) is the main activator of plasminogen into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not. Little is known about the substrates and pathways that mediate plasmin-independent tPA neurotoxicity. Here we show in primary hippocampal neurons that tPA promotes a catalytic-independent activation of the extracellular regulated kinase (Erk)1/2 signal transduction pathway through the N-methyl-D-as ...[more]