Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC1142608 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Li Na N Zhang Yu Y Naylor Matthew J MJ Schatzmann Franziska F Maurer Francisca F Wintermantel Tim T Schuetz Gunther G Mueller Ulrich U Streuli Charles H CH Hynes Nancy E NE
The EMBO journal 20050512 11
Integrin-extracellular matrix interactions play important roles in the coordinated integration of external and internal cues that are essential for proper development. To study the role of beta1 integrin in the mammary gland, Itgbeta1(flox/flox) mice were crossed with WAPiCre transgenic mice, which led to specific ablation of beta1 integrin in luminal alveolar epithelial cells. In the beta1 integrin mutant mammary gland, individual alveoli were disorganized resulting from alterations in cell-bas ...[more]