Ontology highlight
ABSTRACT:
SUBMITTER: Bonaldo MC
PROVIDER: S-EPMC1143750 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Bonaldo Myrna C MC Garratt Richard C RC Marchevsky Renato S RS Coutinho Evandro S F ES Jabor Alfredo V AV Almeida Luís F C LF Yamamura Anna M Y AM Duarte Adriana S AS Oliveira Prisciliana J PJ Lizeu Jackeline O P JO Camacho Luiz A B LA Freire Marcos S MS Galler Ricardo R
Journal of virology 20050701 13
The yellow fever (YF) 17D vaccine is a live attenuated virus. Three-dimensional (3D) homology modeling of the E protein structure from YF 17D virus and its comparison with that from tick-borne encephalitis virus revealed that it is possible to accommodate inserts of different sizes and amino acid compositions in the flavivirus E protein fg loop. This is consistent with the 3D structures of both the dimeric and trimeric forms in which the fg loop lies exposed to solvents. We demonstrate here that ...[more]