The absence of glycoprotein gL, but not gC or gK, severely impairs pseudorabies virus neuroinvasiveness.
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ABSTRACT:
SUBMITTER: Flamand A
PROVIDER: S-EPMC114693 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Publications
The absence of glycoprotein gL, but not gC or gK, severely impairs pseudorabies virus neuroinvasiveness.
Flamand A A Bennardo T T Babic N N Klupp B G BG Mettenleiter T C TC
Journal of virology 20011101 22
Penetration and propagation of herpesviruses in the nervous system require the action of several glycoproteins. To assay for a function of glycoproteins gC, gK, and gL in the neuroinvasiveness of pseudorabies virus (PrV), deletion mutants lacking one of these glycoproteins and corresponding rescuants were inoculated in the nasal cavity of adult mice. We demonstrate that the lack of gL almost prevented the virus from penetrating and propagating in trigeminal, sympathetic, and parasympathetic trac ...[more]
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