Ontology highlight
ABSTRACT:
SUBMITTER: Kent SJ
PROVIDER: S-EPMC114784 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Kent S J SJ Dale C J CJ Preiss S S Mills J J Campagna D D Purcell D F DF
Journal of virology 20011201 23
Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIV(mac239)) DNA or SIV(mac239) DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIV(mac239) DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection ...[more]