Ontology highlight
ABSTRACT:
SUBMITTER: Hou Z
PROVIDER: S-EPMC1150864 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Hou Zhonggang Z Bernstein Douglas A DA Fox Catherine A CA Keck James L JL
Proceedings of the National Academy of Sciences of the United States of America 20050602 24
The Sir1 protein plays a key role in establishing a silent chromatin structure at the cryptic mating-type loci HMR and HML in Saccharomyces cerevisiae by interacting with the bromo-adjacent homology (BAH) domain of the Orc1p subunit of the origin recognition complex (ORC). Here, we present the high-resolution crystal structures of the ORC interaction region (OIR) of Sir1p and that of the complex formed between the OIR and BAH domains. Amino acids within the OIR previously shown to be required fo ...[more]