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ABSTRACT:
SUBMITTER: Wuyts J
PROVIDER: S-EPMC115172 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Wuyts J J De Rijk P P Van de Peer Y Y Pison G G Rousseeuw P P De Wachter R R
Nucleic acids research 20001201 23
The secondary structure of V4, the largest variable area of eukaryotic small subunit ribosomal RNA, was re-examined by comparative analysis of 3253 nucleotide sequences distributed over the animal, plant and fungal kingdoms and a diverse set of protist taxa. An extensive search for compensating base pair substitutions and for base covariation revealed that in most eukaryotes the secondary structure of the area consists of 11 helices and includes two pseudoknots. In one of the pseudoknots, exchan ...[more]