Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization.
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SUBMITTER: Tocchini-Valentini GD
PROVIDER: S-EPMC1157037 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
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Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization.
Tocchini-Valentini Giuseppe D GD Fruscoloni Paolo P Tocchini-Valentini Glauco P GP
Proceedings of the National Academy of Sciences of the United States of America 20050603 25
We have detected two paralogs of the tRNA endonuclease gene of Methanocaldococcus jannaschii in the genome of the crenarchaeote Sulfolobus solfataricus. This finding has led to the discovery of a previously unrecognized oligomeric form of the enzyme. The two genes code for two different subunits, both of which are required for cleavage of the pre-tRNA substrate. Thus, there are now three forms of tRNA endonuclease in the Archaea: a homotetramer in some Euryarchaea, a homodimer in other Euryarcha ...[more]
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