Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.
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ABSTRACT:
SUBMITTER: Hermann GJ
PROVIDER: S-EPMC1165410 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.
Hermann Greg J GJ Schroeder Lena K LK Hieb Caroline A CA Kershner Aaron M AM Rabbitts Beverley M BM Fonarev Paul P Grant Barth D BD Priess James R JR
Molecular biology of the cell 20050420 7
The intestinal cells of Caenorhabditis elegans embryos contain prominent, birefringent gut granules that we show are lysosome-related organelles. Gut granules are labeled by lysosomal markers, and their formation is disrupted in embryos depleted of AP-3 subunits, VPS-16, and VPS-41. We define a class of gut granule loss (glo) mutants that are defective in gut granule biogenesis. We show that the glo-1 gene encodes a predicted Rab GTPase that localizes to lysosome-related gut granules in the inte ...[more]
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