Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
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ABSTRACT:
SUBMITTER: McClung CA
PROVIDER: S-EPMC1166621 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Publications
Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
McClung Colleen A CA Sidiropoulou Kyriaki K Vitaterna Martha M Takahashi Joseph S JS White Francis J FJ Cooper Donald C DC Nestler Eric J EJ
Proceedings of the National Academy of Sciences of the United States of America 20050620 26
Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating the brain's reward circuit. Mice lacking a functional Clock gene display an increase in cocaine reward and in the excitability of dopamine neurons in the midbrain ventral tegmental area, a key brain reward region. These phenotypes are associated with increased expression and phosphorylation of tyrosine hydro ...[more]
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