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Structure-based phylogeny of the metallo-beta-lactamases.

ABSTRACT: The metallo-beta-lactamases fall into two groups: Ambler class B subgroups B1 and B2 and Ambler class B subgroup B3. The two groups are so distantly related that there is no detectable sequence homology between members of the two different groups, but homology is clearly detectable at the protein structure level. The multiple structure alignment program MAPS has been used to align the structures of eight metallo-beta-lactamases and five structurally homologous proteins from the metallo-beta-lactamase superfamily, and that alignment has been used to construct a phylogenetic tree of the metallo-beta-lactamases. The presence of genes from Eubacteria, Archaebacteria, and Eukaryota on that tree is consistent with a very ancient origin of the metallo-beta-lactamase family.

SUBMITTER: Garau G

PROVIDER: S-EPMC1168685 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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Structure-based phylogeny of the metallo-beta-lactamases.

Garau Gianpiero G Di Guilmi Anne Marie AM Hall Barry G BG

Antimicrobial agents and chemotherapy 20050701 7

The metallo-beta-lactamases fall into two groups: Ambler class B subgroups B1 and B2 and Ambler class B subgroup B3. The two groups are so distantly related that there is no detectable sequence homology between members of the two different groups, but homology is clearly detectable at the protein structure level. The multiple structure alignment program MAPS has been used to align the structures of eight metallo-beta-lactamases and five structurally homologous proteins from the metallo-beta-lact ...[more]

PMID: 15980349

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Project description: Not available

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