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Characterization of a novel P[25],G11 human group a rotavirus.

ABSTRACT: A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 to 71%) and amino acid (52 to 76%) sequence identities. This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25].

SUBMITTER: Rahman M

PROVIDER: S-EPMC1169153 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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Characterization of a novel P[25],G11 human group a rotavirus.

Rahman Mustafizur M Matthijnssens Jelle J Nahar Sharifun S Podder Goutam G Sack David A DA Azim Tasnim T Van Ranst Marc M

Journal of clinical microbiology 20050701 7

A novel rotavirus strain (Dhaka6) isolated from a 21-year-old Bangladeshi male patient was characterized by sequence analysis of its VP7 and VP4 gene segments. Phylogenetic analysis of the VP7 gene of the Dhaka6 strain revealed a common evolutionary lineage with porcine G11 rotavirus strains. This isolate is the first reported G11 rotavirus strain infecting a human host. Comparison of the VP4 gene sequences with all currently recognized 24 different P genotypes revealed only low nucleotide (54 t ...[more]

PMID: 16000437

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