Occult Breast Cancer in High-Risk Gene-Positive Pakistani Women Undergoing Contralateral Prophylactic Mastectomy/Prophylactic Mastectomy: Implications for Sentinel Lymph Node Biopsy.

ABSTRACT:

Introduction

Sentinel lymph node biopsy (SLNB) of the axilla is standard in breast cancer (BC) management; however, its role in prophylactic/contralateral prophylactic mastectomy (CPM) is still questioned. To avoid future consequences on surgical morbidity and socioeconomic aspects in low and middle-income countries (LMICs), we intend to determine the prevalence of occult breast cancer (OBC) among CPM cases.

Objective

To determine the prevalence of OBC in patients undergoing prophylactic mastectomy (PM).

Design

This is a retrospective cohort study.

Materials and methods

This retrospective cohort study is conducted at a tertiary-care hospital from January 2017 to December 2022. All individuals with the positive genetic test for high-risk breast cancer (HRBC) gen

SUBMITTER: Mooghal M 

PROVIDER: S-EPMC11694291 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature