Ontology highlight
ABSTRACT:
SUBMITTER: Onwueme KC
PROVIDER: S-EPMC1169502 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Onwueme Kenolisa C KC Vos Cheryl J CJ Zurita Juan J Soll Clifford E CE Quadri Luis E N LE
Journal of bacteriology 20050701 14
Diacyl phthiocerol esters and their congeners are mycobacterial virulence factors. The biosynthesis of these complex lipids remains poorly understood. Insight into their biosynthesis will aid the development of rationally designed drugs that inhibit their production. In this study, we investigate a biosynthetic step required for diacyl (phenol)phthiocerol ester production, i.e., the reduction of the keto group of (phenol)phthiodiolones. We utilized comparative genomics to identify phthiodiolone ...[more]