Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution.
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ABSTRACT:
SUBMITTER: Dan I
PROVIDER: S-EPMC117062 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Publications
Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution.
Dan Ippeita I Watanabe Norinobu M NM Kajikawa Eriko E Ishida Takafumi T Pandey Akhilesh A Kusumi Akihiro A
Nucleic acids research 20020701 13
Overlapping of genes, especially in an anti-parallel fashion, is quite rare in eukaryotic genomes. We have found a rare instance of exon overlapping involving CHRNE and MINK gene loci on chromosome 17 in humans. CHRNE codes for the epsilon subunit of the nicotinic acetylcholine receptor (AChRepsilon) whereas MINK encodes a serine/threonine kinase belonging to the GCK family. To elucidate the evolutionary trail of this gene overlapping event, we examined the genomes of a number of primates and fo ...[more]
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