Ontology highlight
ABSTRACT:
SUBMITTER: Lakshmanan V
PROVIDER: S-EPMC1173140 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Lakshmanan Viswanathan V Bray Patrick G PG Verdier-Pinard Dominik D Johnson David J DJ Horrocks Paul P Muhle Rebecca A RA Alakpa George E GE Hughes Ruth H RH Ward Steve A SA Krogstad Donald J DJ Sidhu Amar Bir Singh AB Fidock David A DA
The EMBO journal 20050609 13
Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the contribution of individual pfcrt mutations has not been clarified and other genes have been postulated to play a substantial role. Using allelic exchange, we show that removal of the single PfCRT amino-acid change K76T from resistant strains leads to wild-type levels of CQ susceptibility, increased binding of CQ to its target ferriprotoporphyrin IX ...[more]