Ontology highlight
ABSTRACT:
SUBMITTER: Kline DD
PROVIDER: S-EPMC117389 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Kline David D DD Peng Ying-Jie YJ Manalo Dominador J DJ Semenza Gregg L GL Prabhakar Nanduri R NR
Proceedings of the National Academy of Sciences of the United States of America 20020115 2
To investigate whether the transcriptional activator hypoxia-inducible factor 1 (HIF-1) is required for ventilatory responses to hypoxia, we analyzed mice that were either wild type or heterozygous for a loss-of-function (knockout) allele at the Hif1a locus, which encodes the O(2)-regulated HIF-1 alpha subunit. Although the ventilatory response to acute hypoxia was not impaired in Hif1a(+/-) mice, the response was primarily mediated via vagal afferents, whereas in wild-type mice, carotid body ch ...[more]